I-sesamol

I-sesamol powder Ulwazi oluyisisekelo

Igama	I-Sesamol powder
Ukubukeka	powder emhlophe
CAS	533-31-3
yokuncwaninga izinsimbi kanye namakhemikhali	≥99%
solubility	I-nsoluble emanzini noma utshwala, i-soluble ku-Acetic acid, i-ethyl ester.
Isisindo seMolar	I-138.12 g / mol
Melt Point	62 ku-65 ° C (144 kuya ku-149 ° F; 335 kuya ku-338 K)
Formula Yamamolekhula	C7H6O3
Iphuzu lokubilisa	21 kuya ku-127 ° C (250 kuya ku-261 ° F; 394 kuya ku-400 K) ngo-5
SMILES	mmHgO1c2ccc (O) cc2OC1

 

Kuyini I-sesamol?

I-Sesamol iyinhlanganisela yemvelo ye-phenol etholakala ku-oyela we-sesame osetshenzisiwe kanye nembewu ye-sesame eyosiwe. I-Sesamol (i-CAS 533-31-3) kubhekwa njengengxenye enkulu esebenzayo kawoyela we-sesame obamba iqhaza emiphumeleni yawo yokwelapha.

Isesame (Isibonakaliso seSesamum) i-oilseed ebalulekile emndenini wePedaliaceae. Ithathwa njengenye yamafutha asendulo amadala aziwa futhi asetshenziswa ngumuntu hhayi nje ngokubaluleka kokudla okunempilo kepha nangokubaluleka kwezokwelapha. Izingxenye ezinkulu zesame ezinikeza inani lokwelashwa ngamaqabunga kanye noyela wembewu.

Inhlanganisela yeSesamol 533-31-3 itholakala ngamanani wokulandelela ngaphandle kwamanye ama-lignin compounds ka-sesame oil, sesamin kanye ne-sesamolin. Le nhlanganisela yamanzi encibilikayo ithathwa njenge-antioxidant enamandla.

 

Ngabe sesamol work?

ISesamol isebenza ngezindlela ezahlukahlukene ukunikela ngezinzuzo zayo ezinkulu zokwelapha ezifana ne-neuroprotection, imiphumela ye-antioxidant, anti-inflammatory, anti-tumor, anti-radiation kanye nemiphumela enamandla yokuhlwitha.

Ngezansi kunezindlela ezithile lapho i-sesamol isebenza khona ukufeza imiphumela eshiwo;

 

I. Ivimbela ukulimala kwe-DNA ngokucindezeleka okwenziwe nge-oxidative

I-Sesamol ingavimbela ukulimala kwe-DNA ngokucindezeleka okubangelwa yimisebe. Imisebe ye-Ionizing ibangela ukulimala kwe-DNA yeselula ngokunciphisa ukuphazamiseka kwe-chromosomal kanye ne-micronuclei kumaseli akhulayo.

 

II. Kushukumisa umsebenzi wama-antioxidants abalulekile

I-Sesamol iyasebenza ngokulawula phezulu imisebenzi yama-enzyme abalulekile e-antioxidant anjenge-catalase (CAT), superoxide dismutase (SOD), ne-glutathione peroxidase (GPx), ehambisana namazinga akhuphukile we-glutathione (GSH) ancishisiwe. La ma-enzyme adlala indima ebalulekile ekuvikeleni ukulimala kwamaselula ngama-radicals.

 

III. Ivimbela amaprotheni we-pro-apoptotic ngaleyo ndlela athuthukise ukusebenza kweseli

Ama-pro-apoptotic protein amaprotheni akhuthaza ukufa kwamaseli. Kubandakanya i-p53, i-caspase-3, i-PARP, nama-enzyme amabi. La ma-enzyme ayabandakanyeka ekufeni kweseli okuhleliwe ngakho-ke kunganciphisa ukusebenza kwamaseli.

I-Sesamol ikhonjisiwe ukuthi ikhuthaza ukusebenza kwamaseli ngokuvimbela umsebenzi wama-enzyme we-pro-apoptotic.

 

IV. Ukuvimbela i-lipid peroxidation

I-lipid peroxidation uhlobo lokucekelwa phansi kwe-lipid okwenzeka ngenxa ye-oxidation. Lokhu kuphumela ekwakhiweni kwama-aldehydes asebenzayo, njenge-malondialdehyde (MDA) ne-4-hydroxynonenal (HNE) edala ukulimala kwamaseli. I-Sesamol ikhonjisiwe ukuthi ivimbela i-lipid peroxidation ngakho-ke inikeza ukuvikelwa kumaseli.

 

V. Ivimbela ukwenziwa kwama-radical mahhala kufaka phakathi ama-hydroxyl radicals

Ama-radicals amahhala ayizinhlanganisela ezingazinzile ezihlotshaniswa nezifo nokuguga. Ama-radicals e-Hydroxyl yizona zinto ezinamandla kakhulu ezibangela ukugula.

I-Sesamol inciphisa ukukhiqizwa kwama-radicals amahhala kufaka phakathi i-hydroxyl, α, α-diphenyl-β-picrylhydrazyl (I-DPPH), kanye ne-ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid).

 

VI. Ithuthukisa umsebenzi omkhulu wokuhlwitha

Ngaphezu kokuvimbela ukukhiqizwa kwama-radicals amahhala, i-sesamol iyakwazi ukuqeda ama-radicals amahhala njenge-hydroxyl, lipid peroxyl kanye ne-tryptophanyl radicals.

 

VII. Ukucindezela amaseli wokuvuvukala

I-Sesamol ivimbela izindlela zokusayina ezibandakanyeka ekukhiqizweni kwezinhlobo ezisebenzayo ngakho-ke kunciphisa impendulo yokuvuvukala.

 

VIII. Yehlisa ama-cytokines wokuvuvukala (TNFα, IL-1β, ne-IL-6)

I-nitric oxide, ekhiqizwa yi-iNOS, iholela ekuvukeleni kwamaphaphu ngokuvuselela ama-cytokines wokuvuvukala, njenge-TNFcy, nokwenza ngcono impendulo yokuvuvukala. I-Sesamol inamandla okuvimbela ukukhishwa kwe-TNFcy ne-IL-1β.

 

IX. Ukuboshwa kokukhula kwamaseli ngezigaba ezahlukahlukene

I-Sesamol ikhonjisiwe ukuthi ibangele ukuboshwa kokukhula kwamaseli ezigabeni ezahlukahlukene zokukhula kwamangqamuzana kufaka phakathi isigaba S kanye nesigaba se-G0 / G1. Izici zomdlavuza weSesamol ngakho-ke ziyasiza, ngokwesibonelo, ukunciphisa ukukhula kwamangqamuzana omdlavuza.

 

X. Ukwenza kusebenze indlela ye-caspase

Ama-caspase angama-enzyme abandakanyeka ekufeni okuhleliwe kweseli. I-Sesamol ikhonjisiwe ukuthi ivule lezi zindlela okuholela ekufeni komdlavuza weseli.

 

XI. Iheha i-apoptosis ngezindlela zangaphakathi nezingaphandle

I-apoptosis inqubo yomzimba lapho kwenzeka khona ukufa kwamaseli ahleliwe. Kuyindlela ebalulekile njengoba isiza umzimba ukuqeda amaseli afile.

ISesamol iheha i-apoptosis ngezindlela ezimbili ezihlukile, izindlela zangaphakathi nezangaphandle.

 

XII. Ivimbela i-autophagy ye-mitochondrial

I-Mitochondrial autophagy uhlobo oluthile lokucekelwa phansi okusiza ukuqeda i-mitochondria enesici.

Lapho i-sesamol ivimbela le nqubo, khona-ke i-apoptosis iyenziwa.

 

XIII. Yehlisa amazinga e-nitrite ne-neutrophil

Ama-nitrites nama-neutrophils adlala indima ekuphenduleni kokuvuvukala. Babandakanyekile ekukhishweni kwe-nitric oxide elawula impendulo yokuvuvukala ngokunciphisa noma ngokuvimbela ukuvuvukala.

I-Sesamol idlala indima njenge-ejenti elwa nokuvuvukala ngokunciphisa amazinga ama-nitrites nama-neutrophils.

 

Kuyini i-sesamol esetshenziselwe?

ISesamol isetshenziselwa izinzuzo ezahlukahlukene zezempilo kufaka phakathi;

 

i. Umfutho wegazi ophezulu.

Amafutha eSesame asetshenziswa kanye nezidakamizwa ezimbalwa zegazi njengemithi efakazelwe yokwehlisa umfutho wegazi.

Ucwaningo olubanzi ngamafutha esesame luveza ukuthi i-sesamol ne-sesamin (ama-lignans atholakala ku-oyela wesame) adlala indima enkulu ekulawuleni umfutho wegazi. Ukuthatha uwoyela we-sesame, upheka kakhulu ngawo, amasonto amathathu kwehlisa umfutho wegazi wabantu abanomfutho wegazi ophezulu baye kokujwayelekile.

Ngesikhathi kwenziwa ucwaningo, abasebenza kwezokwelapha bafaka iqembu leziguli ezinomfutho ophakeme emithini (iProcardia, Nefedica ne-Adelta) isikhathi esiyizinsuku ezingama-21. Yize kube nokuncipha okuncane kwengcindezi yabo yegazi, bekungakajwayelekile. Uwoyela weSesame wasetshenziswa esikhundleni semithi, kanti iziguli zahlolwa ngemuva kwesikhathi esifanayo. Umphumela waba ukuthi umfutho wegazi labo wehlele kokujwayelekile.

Odokotela baphikise ngokuthi umphumela ube negalelo elikhulu ngamanani aphezulu esesamol ne-sesamin emafutheni esitshi aphekiwe. Uma lokho kutholakala ukuthi kufaka phakathi uwoyela wesame ekudleni kwabantu abane-high blood pressure kungasebenza kakhulu kunokubanikeza imishanguzo.

Le miphumela yabikwa kwi-American Heart Association ngesikhathi somhlangano waminyaka yonke we-Inter-American Society of Hypertension nguSolwazi Devarajan Sankar wase-Annamalai University, e-India.

 

ii. Ukuvaleka emathunjini.

Ukucwaninga ngemiphumela ye-sesamol ekuvalekeni kwamathumbu kusikisela ukuthi kungaba ngcono kakhulu kune-aspirin. Kucwaningo olumayelana ne-ulcerative colitis, i-IBD (isifo sokuvuvukala kwamathumbu), esidala ukulimala kwezicubu ze-mucosal ngokudambisa uhlelo lokuvuvukala. Ocwaningweni olubandakanya amagundane, i-sesamol itholwe ukunciphisa imisebenzi yama-enzyme abangela ukuvuvukala.

Yize i-aspirin yaziwa ngokubulala ngempumelelo ukuphazamiseka kokuvuvukala lapho ifakwa, ingaholela ekuthuthukisweni kwezilonda ekusetshenzisweni kwesikhathi eside. I-Aspirin ibangela ukulimala kwe-gastroduedonal ngokuqeda amaseli.

Ucwaningo olwengeziwe lukhombisa ukuthi i-nasogastric intubation ye-sesamol ezigulini ezinesifo esincane samathumbu kanye nokunakekelwa okujwayelekile kwehlisa amathuba okuhlinzwa.

 

iii. Isifo senhliziyo.

Izici zobungozi ezibangelwa izifo zenhliziyo nemithambo yegazi zinengxenye enkulu ekufeni nasemhlabeni wokugula. Zingaholela ekucindezelekeni kwe-oxidative futhi uma kungalashwa kungabi kubi kakhulu ekukhuleni kwezinhlobo ze-oksijeni ezisebenzayo zokukhiqiza, kufaka phakathi uhlelo lokuvikela oluphikisiwe.

I-Sesamol isebenzisa izakhiwo zayo ezilwa ne-oxidative ukuvimbela izifo ezinobungozi ezinjenge-hypercholesterolemia, i-hypertriglyceridemia, i-high-density lipoprotein cholesterol ne-high-density lipoprotein.

Olunye uphenyo seluphethe ngokuthi i-sesamol inolwelwesi oluzinzile kanye nemiphumela yokwehlisa i-lipid. Ngaphezu kwalokho, ihlinzeka ngokuvikela i-myocardium ekulweni ne-cardiomyopathy eyenziwe nge-DOX.

 

IV. Ukukhula kwengane.

I-Sesamol isetshenziswa ezinhlotsheni eziningi zokukhula kwengane. Ezifundweni ezahlukahlukene, i-sesamol esetshenziselwa ukunciphisa i-ADHD ezinganeni eziphazamiseke ngokwengqondo yabizwa ngokuthi iyasebenza kancane uma isetshenziswa ngamanani amancane. Ukushoda kwe-DHA kuvame kakhulu ezinganeni ezine-ADHD.

Ukucwaninga okungaphezu kweshumi kukhombisa izinzuzo ezithandekayo kwizimpawu ze-ADHA kufaka phakathi ukufundwa kwamagama, ukungacabangi, ukufunda okubukwayo, inkumbulo yokusebenza, kanye nokusebenza ngokweqile.

Izinsana ezibhucungwa ngamafutha esesame amasonto amane zaqopha ukukhula okuthuthukile nokusebenza ngokomzimba.

 

v. Isifo sikashukela.

I-Sesamol isebenza ngempumelelo njengesengezo emithini yesifo sikashukela ukwehlisa amazinga kashukela egazini ngokushesha. Ukuthatha izithasiselo ze-sesamol noma kunalokho ushintshele ekudleni kwamafutha esesame ngenkathi unesifo sikashukela kunika isivuno esingcono somsebenzi.

Ekucwaningweni okuningana, okubandakanya kakhulu iziguli ezinesifo sikashukela sohlobo lwe-2, i-sesamol iveze imiphumela emihle. Esinye sezifundo sasihilela amaqembu amathathu, ngalinye liphethwe yisifo sikashukela sohlobo 2. Iqembu elilodwa beliphethwe i-sesamol lilodwa, elinye liphuziswa umuthi wansuku zonke we-glibenclamide (Glyburide), kanti elokugcina kuwo womabili ama-sesamol kanye neGlyburide isikhathi esingamasonto ayi-7.

I-Sesamol kubikwa ukuthi inomphumela wokusebenzisana ne-glyburide, njengoba ukwelashwa okuhlanganisiwe kwehlise kakhulu ama-hemoglobin A1c namazinga kashukela egazini kakhulu, futhi angcono kakhulu kunenye yezindlela zokwelapha ezilodwa.

Hyperlipidemia. Abaphenyi babika ukuthi i-sesamol esetshenziselwa ukushisa i-cholesterol namanye ama-lipids egazini inikeze imiphumela emihle. Ekuhlolweni okuyimodeli, ukusebenza kwe-sesamol kuhlolwe ku-hyperlipidemia enamafutha aphezulu, i-hyperlipidemia engapheli, i-hypercholesterolemia, ne-acute hyperlipidemia.

Kwehliswe amazinga e-triacylglycerol njengoba imiphumela yokugcina iphakamise ukuthi i-sesamol inciphisa kakhulu ukumuncwa kwe-triacylglycerol. I-Sesamol nayo isetshenziselwa ukuguqula amazinga aphezulu e-cholesterol.

Ucwaningo lukhombisa ukuthi i-sesamol supplement inyusa ukukhishwa kwe-cholesterol kanye nokunciphisa ukumuncwa kwayo.

 

VI. I-Metabolic syndrome nokukhuluphala ngokweqile.

ISesamol kubikwa ukuthi iqukethe amakhono ahlukahlukene wezinto ezibandakanya ikhono lokubuyisa ukukhuluphala nokuphazamiseka komzimba. Kubikwa ukuthi kungavimbela imiphumela yokulwa nokukhuluphala.

Ucwaningo olwenziwe ukuhlola ukuthi i-sesamol isebenza kanjani ekukhuluphaleni, kutholakale ukuthi ingalawula i-hepatic lipid metabolism. Lokhu kamuva kuthuthukise ukumelana ne-insulin futhi kwenyusa ukwehla kwesisindo. Ukukhuluphala kanye nokuphazamiseka okuhlobene nakho kwe-metabolic kuhlobene kakhulu nokuqongelela kwe-lipid emzimbeni. Ukuncipha kokuncipha kusho ukuthambekela kokukhuluphala okuguqulwayo.

Ukusetshenziswa kweSesamol kwandisa i-lipolysis, i-fatty acid oxidation nokwehlisa izinga le-lipogenesis ye-hepatic, izinto ezibalulekile ekwehliseni ukuqongelela kwe-lipid. Le misebenzi (okusho ukutholwa kwe-lipid, synthesis kanye ne-catabolism) iphakathi kokuningi okwenzeka esibindini.

Abantu abasebenzisa i-sesamol babike amaphrofayili we-hepatic ne-serum lipids angcono, futhi baphinde bathuthukisa ukuzwela kwe-insulin.

 

vii. Isifo samathambo, i-Osteoarthritis, ne-osteoporosis.

Yize i-rheumatoid arthritis, isifo esibuhlungu futhi esingapheli se-autoimmune, inezindlela zokwelapha zamakhemikhali eziningana, ukusetshenziswa kwazo isikhathi eside kuvame ukuba yi-hepatotoxic. I-Sesamol ingaba ikhambi lemvelo elingaba khona. Ucwaningo oluphenya okufanayo lubike ukuthi i-sesamol inemiphumela engcono yokulwa ne-arthritic kanye ne-anti-inflammatory eyenze ngcono imiphumela ye-rheumatoid arthritis.

I-Osteoarthritis iyinto enkulu ebambe iqhaza ezinhlungwini ezihlangene, okucatshangwa ukuthi ingathinta cishe i-15% yabantu emhlabeni jikelele. Ukucindezeleka okwenziwe nge-oxidative, noma kunjalo, kunendima enkulu ekungasebenzi kahle kwemisipha yamathambo. Ukucwaninga ngemiphumela ye-sesamol kubuhlungu obuhlangene obuhambisana ne-osteoarthritis kukhombisile ukuthi ukuthatha isesamu sesengezo isonto lonke kungehlisa ubuhlungu. Lokhu kubangelwe yimpahla yokulwa nengcindezi elwa ne-oxidative ye-sesamol.

Ososayensi baphethe ngokuthi inqubo efanayo ne-postmenopausal osteoporosis isihambile ukudala i-ovariectomy, lapho kuncipha ngokuqhubekayo kwesisindo samandla namandla. Ngakho-ke kutholakala ukuthi ukulahleka kwethambo kubangelwa kakhulu yi-estrogen. I-Sesamol kubikwa ukuthi ibophezela kuma-estrogen receptors futhi yenze ukuloba kwezakhi zofuzo okuphendula nge-estrogen. Imiphumela ezuzisayo ithuthukisa amandla amathambo ngokukhiqiza amaprotheni we-matrix.

 

viii. Isifo i-Alzheimer, ukukhathazeka kanye nesifo sohlangothi.

Isifo i-Alzheimer ukukhubazeka kobuchopho okuqhubekayo okuholela ekuwohlokeni kwamangqamuzana obuchopho. Imvamisa iqeda ukuzimela kwengqondo kwabantu abathintekile. Imiphumela yokwelashwa kwe-sesamol ibikwe ukuthi iyathembisa. Ucwaningo lwaluhlelelwe ukucacisa amandla okwelashwa e-sesamol ku-isithuthwane, isimo esixhunyaniswe kabanzi nokukhubazeka kwengqondo kanye nengcindezi ye-oxidative. Ucwaningo luphethe ngokuthi i-sesamol ikhiphe imiphumela yokuzijabulisa ekulweni nesifo sohlangothi, ukukhubazeka kwengqondo, ukuqubuka kanye nengcindezi ye-oxidative. Ukusetshenziswa kweSesamol kwemithi elwa nesifo sokuwa kungaba lusizo.

 

Izinzuzo zeSesamol

[a]. I-sesamol Anti-oxidant imiphumela

Ukucindezeleka okwenziwe nge-oxidative kwenzeka lapho kunokungalingani ekukhiqizeni kwama-radicals mahhala kanye nama-antioxidants emzimbeni. Lokhu kuvame ukuholela ekulimaleni kweseli nasekucindezelekeni kwe-oxidative kuthathwa njengembangela yezinkinga eziningi.

Ukucindezeleka okwenziwe nge-oxidative nokho kuyinqubo engokwemvelo yomzimba eholela nasekugugeni.

Ama-antioxidants ngakolunye uhlangothi yizinto ezivimbela ukonakala kwamaseli ngenxa yama-radicals wamahhala. Zivame ukubizwa ngokuthi ama-radicals free scavengers.

I-Sesamol iyinhlangano enamandla kakhulu futhi enamandla e-antioxidant yamafutha we-sesame. Isebenza ngezindlela ezahlukahlukene zokuletha imiphumela ye-antioxidant. Lezi zinqubo zokusebenza zibandakanya ukukhuphula umthethonqubo wezinto ezibalulekile ze-antioxidant, ukuvikelwa kwe-DNA ekulimaleni kwemisebe, ukuqeda ama-radicals wamahhala, ukuvimbela i-lipid peroxidation, nokuvikelwa emisebeni ye-ultraviolet.

Ucwaningo oluhlola umsebenzi we-radioprotective we-sesamol ngokumelene ne-gamma irradiation ku-DNA. Ukulimala kwe-DNA kubangelwa ukwethula ikhefu elilodwa noma elinezintambo ezimbili ngokuzalaniswa kwezinhlobo zomoya-mpilo ezisebenzayo.

USesamol watholakala evimbela amakhefu e-DNA abambeke emgodini owodwa. Iphinde yehlisa amazinga ama-radicals wamahhala ikakhulukazi i-hydroxyl, i-DPPH, ne-ABTS radicals, konke okwakuxhunyaniswe nekhefu elethwe elilodwa noma elikabili.

 

[b]. I-sesamol Anti-inflammatory izinzuzo

Ukuvuvukala kuyinqubo engokwemvelo yomzimba umzimba oyisebenzisayo ukulwa nama-agent angaphandle anjengebhaktheriya, isikhunta, noma ukulimala. Kodwa-ke, ukuvuvukala okungapheli kuyingozi emzimbeni njengoba kuholela ekuphazamisekeni okuhlukahlukene.

Ama-anti-inflammatory agents asiza ukuvikela umzimba ekulimaleni ngokulwa nokuvuvukala. I-Sesamol isebenza ngezindlela ezahlukahlukene zokunikela ngemiphumela yokulwa nokuvuvukala. Lezi zindlela zokusebenza zifaka phakathi ukuvimbela amaseli wokuvuvukala, ukunciphisa ukukhiqizwa kwe-nitrites kanye nokucindezela umsebenzi nezindlela zokuvuvukala.

Ekucwaningweni kwamagundane ane-lipopolysaccharide LPS eyenziwe ukulimala kwamaphaphu, i-sesamol itholakale icindezela ama-cytokines alwa nokuvuvukala futhi yavimbela ukukhiqizwa kwe-nitric oxide ne-prostaglandin E2 (PGE2). ISesamol nayo yatholakala ukuthi ilawula ukusebenza kwe-adenosine monophosphate-activated protein kinase (AMPK) activation. Lokhu kusiza ukucindezela ukuvuvukala futhi kunciphise nokulimala kweseli.

[c]. Umdlavuza weSesamol anti imiphumela

I-sesamol inezakhiwo ezisiza ukulwa namaseli anomdlavuza kufaka phakathi umsebenzi wokulwa nokwanda ngokusebenzisa izindlela ezahlukahlukene njengokuvimbela amandla we-membrane, ukubamba ukukhula kwamaseli ngezigaba ezahlukahlukene kanye nokunciphisa i-apoptosis.

Ocwaningweni olubandakanya ulayini womdlavuza wamangqamuzana womuntu we-DLD-1, i-sesamol yasetshenziswa kumthamo we-12.5-100 μM. Kutholakale ukuthi umsebenzi wokubhala we-COX-2 wehle ngo-50%.

Kwesinye isifundo, i-sesamol esetshenziswe kumthamo ophakeme we-0.5-10 mM itholwe ukuthi yenze i-apoptosis ku-HCT116 ngokwandisa i-intracellular reactive oxygen (O2 • -) ngendlela encike kumthamo. Lokhu kuholele ekusebenzeni kwendlela yokusayina ye-JNK ekhuthaza ukulimala kwe-mitochondrial. Lokhu kuphumela ekukhishweni kwe-cytochrome c egcina isebenze i-caspase ngaleyo ndlela inciphise i-apoptosis.

 

[d]. I-Seasomol I-anti-mutagenic imiphumela

I-Mutagenicity ibhekisa emandleni e-ejenti (mutagen) ukudala izinguquko. Ukuguqulwa okuguqukayo ezintweni zofuzo kungaholela ekulimaleni kweseli futhi kubhekwe njengokudala izifo ezithile ezifana nomdlavuza.

I-Sesamol ikhonjisiwe ukuthi inezindawo ezinamandla zokulwa ne-mutagenic. Izinzuzo zayo zokulwa ne-mutagenic zibangelwa umsebenzi we-antioxidant futhi ikakhulukazi amandla okuthola ama-radicals wamahhala.

Ocwaningweni, i-mutagenicity yenziwa ukukhiqizwa kwama-oxygen radicals yi-tert-butylhydroperoxide (t-BOOH) noma i-hydrogen peroxide (H2O2). ISesamol itholakale ukuthi inemiphumela enamandla yokulwa ne-mutagenic kuma-Ames tester strains TA100 ne-TA102. Uhlobo lwe-TA102 lwaziwa ukuthi luzwela kakhulu ezinhlotsheni ze-oxygen ezisebenzayo. I-Sesamol iphinde yaboniswa ukuthi ivimbela i-mutagenicity ye-sodium azide (Na-azide) kuhlobo lwe-TA100 lokuhlola.

 

[e]. I-sesamol Protection kusuka emisebeni

Imisebe isho amandla ahamba ngendlela yamagagasi noma izinhlayiya. Imisebe ingenzeka kakhulu endaweni yethu. Kodwa-ke, imisebe ye-ionizing ingaba yingozi uma ishiywa ingalawulwa. Ukuvezwa okuncane emisebeni kungaholela ezifweni ezinzima ezifana nokugula kwemisebe nokushiswa yilanga.

Ukuvezwa okwandisiwe kwemisebe kubangela ukuphazamiseka okukhulu okubandakanya umdlavuza nesifo senhliziyo.

Ekucwaningweni kwamagundane anomonakalo owenziwe ngemisebe ye-DNA, i-sesamol yahlolwa ngomsebenzi wayo wokuzivikela emisebeni. Ukwelashwa kabusha kwamagundane nge-sesamol kuholele ekuvikelekeni ekulimaleni kwe-DNA okubangelwa yimisebe.

 

[f]. I-Cardioprotection

USesamol kubikwe ukuthi unikela ngokuvikela enhliziyweni ekulimaleni.

Ocwaningweni lokuhlola amandla okuvikela i-sesamol ekulimaleni kwe-myocardial, ukwelashwa kwe-sesamol kwenziwa ku (50 mg / kg) kwenziwa izinsuku eziyi-7 ngaphambi kwesikhathi sokuhlinzwa.

Lolu cwaningo luthole ukuthi i-sesamol yehlise kakhulu usayizi we-infarct, yafaka izimpawu zomzimba, yavimbela i-lipid peroxidation, ukungena kwe-neutrophil kanye nokwenyusa izinga le-antioxidants.bikwa ukuthi i-sesamol powder iholela ekwehleni kwezakhi zofuzo ezivuthayo, amaprotheni we-Caspase-3 apoptotic , futhi iphinde yathuthukisa umsebenzi we-anti-apoptotic Bcl-2 protein.

 

[g]. I-sesamol Ama-radicals wamahhala ahlaselayo

Ama-radicals amahhala ngama-athomu angazinzile athola kalula ama-electron kwamanye ama-athomu. Zombili zinenzuzo futhi zinobuthi ngokuya ngokuhlushwa kwazo. Emazingeni aphansi ama-radicals wamahhala adlala indima ekuphenduleni kwamagciwane, noma kunjalo, lapho ukugxila kwabo kuphakeme kakhulu baba yingozi. Ama-radicals amahhala akhula nengcindezi ye-oxidative engalimaza amaseli futhi ingadala ukuphazamiseka okungapheli nokuwohloka okunjengomdlavuza, izifo zenhliziyo, nesifo samathambo, i-cataract, kanye nezifo ze-neurodegenerative.

Imizimba yethu ilwa nemiphumela yengcindezi ye-oxidative ngokukhiqiza ama-antioxidants kepha kungenzeka anganeli futhi adinga ukwengezelelwa ngokudla noma izithasiselo.

I-Sesamol inekhono lokuvimbela ukwakheka kwama-radicals wamahhala kanye nokusabalalisa ama-radicals wamahhala.

Ocwaningweni oluhlanganisa amaseli amadala esikhumba esikhumba esikhumba somuntu (i-HDFa) evezwe ku-UVB, ukwelashwa kwe-sesamol kwahlolwa ngokumelene ne-cytotoxicity, amazinga we-oksijeni asebenzayo we-intracellular (ROS), i-lipid peroxidation, isimo se-antioxidant, kanye nomonakalo we-DNA we-oxidative. ISesamol itholwe ukuthi yehlisa kakhulu i-lipid peroxidation, i-cytotoxicity, i-ROS ye-intracellular, kanye nomonakalo we-DNA oketshezi kumaseli wesikhumba esikhumba somuntu. Lokhu kubangelwe ikhono lesengezo se-sesamol ukukhipha i-ROS.

Ucwaningo olufanayo lubike ukwanda komsebenzi we-enzymatic non-enzymatic onomthelela ekusebenzeni kangcono kwe-antioxidant.

 

[h]. Kwehlisa i-cholesterol egazini

I-cholesterol yegazi yinto efana namafutha, into emuncu emzimbeni wakho. Iyadingeka ngumzimba ukwakha amaseli aphilile kepha ngamanani alungile. I-cholesterol ithuthwa ngezinhlobo ezimbili zama-lipoprotein, i-low-density kanye ne-high-kwabantu. Ngaleyo ndlela kuletha izinhlobo ezimbili ze-cholesterol, i-cholesterol ephansi ye-lipoprotein (LDL), ne-cholesterol ephakeme kakhulu (i-HDL).

I-LDL ivame ukubizwa nge-cholesterol embi kusukela emazingeni aphezulu we-LDL kwandisa ingozi yokuba nomthambo futhi nezinye izifo.

I-Sesamol inganciphisa izinga le-cholesterol kanye nezinga le-triacylglycerol emzimbeni.

Ekuhlolweni kokubekezelelana kwamafutha, i-sesamol (100 no-200 mg / kg) itholwe kakhulu (P <0.05) inciphisa ukumuncwa kwe-triacylglycerol yingakho yehlisa izinga le-triacylglycerol emzimbeni. I-Triacylglycerol ingxenye eyinhloko yamafutha agcinwe ezicutshini ze-adipose.

Ekucwaningweni kwamagundane aseSwitzerland albino ane-hyperlipidemia eyenziwe, isengezo se-sesamol ku-50 no-100 mg / kg kubikwe ukuthi kwehle kakhulu amazinga e-cholesterol ne-triacylglycerol kakhulu.

Umsebenzi we-sesamol owehlisa amazinga we-cholesterol kanye ne-triacylglycerol ubangelwa ikhono lawo lokunciphisa ukumuncwa kanye nokwandisa ukuphuma kwe-cholesterol.

 

[i]. I-Sesamol izuzisa isikhumba

Isikhumba somuntu siyingxenye esemqoka yohlelo lwama-integumentary umsebenzi wawo oyinhloko ukuvikela izitho zomzimba.

I-Sesamol izuzisa isikhumba ngezindlela ezahlukahlukene ngenxa yezakhiwo zayo ezinamandla kubandakanya i-antioxidant, kanye nomsebenzi olwa nokuvuvukala. I-Sesamol izuzisa isikhumba nge

 

· Ukuvikela isikhumba emisebeni ye-ultraviolet (UV)

Ukuchayeka isikhathi eside ekukhanyeni kwelanga kungaholela esizukulwaneni esingajwayelekile esiphezulu sezinhlobo zomoya-mpilo ezisebenzayo (i-ROS), ezingadala ukulimala kwesikhumba njengokucekelwa phansi kwe-collagen ku-dermis kanye ne-hyperplasia ye-epidermis.

ISesamol iyakwazi ukukhipha ama-radicals amahhala avela ngenxa yokuchayeka isikhathi eside elangeni ngaleyo ndlela ivikele isikhumba ekulimaleni kwe-DNA yemisebe. Inikeza isembozo esivikelayo esisiza ukuvikela isikhumba ekulimaleni yimisebe ye-UV.

Ucwaningo lubika ukuthi i-sesamol inganciphisa i-cytotoxicity eyenziwe nge-UVB. Kubikwa futhi ukuthi kuvimbela i-melanin biosynthesis ngokwehlisa ukubonakaliswa kwe-tyrosinase, MITF, TRP-1, TRP-2, ne-MC1R kumaseli e-melan-a.

Olunye ucwaningo luthole ukuthi i-sesamol nayo ingaphazamisa ukuhlanganiswa kwe-melanin ngokuthonya i-CAMP / protein kinase A (cAMP / PKA), protein kinase B (AKT) / glycogen synthase kinase 3 beta (GSK3β) / CREB, TRP-1, ne-MITF ku-B16F10 amaseli

 

· Siza ukugcina isikhumba esikhanyayo

I-Sesamol yaziwa njenge-antioxidant enamandla. Ingena ngokujulile esikhunjeni ngaleyo ndlela yondle isikhumba. Lokhu nakho kusiza ukuthola isikhumba esikhanyayo.

 

· Iqeda induna

Izinduna yisimo lapho izimbotshana zesikhumba zigcwele uwoyela, ukungcola nezinye izinto eziyingozi.

I-sesamol inezinto ezilwa namagciwane ezikwenza ikwazi ukuqeda amagciwane ngakho-ke uthola isikhumba ngaphandle kwezinduna.

 

· Inikeza imiphumela yokulwa nokuguga

Ukuguga kuyinqubo yokuphila elinganiselayo neqhubekayo. Kodwa-ke ukuguga ngaphambi kwesikhathi kungenzeka ngenxa yezici eziningana njengokuchayeka isikhathi eside emisebeni ye-UV, ukucindezeleka okwenziwe nge-oxidative phakathi kwabanye.

I-Sesamol inikeza umsebenzi onamandla we-antioxidant ovimbela isikhumba nomzimba ekungeneni kwe-cellular futhi kuthuthukise ukuvuselelwa kwesikhumba.

ISesamol nayo kubikwe ukuthi ivimbela ukuvela kolayini, izimbotshana nemibimbi.

 

[j]. Izinzuzo zeSesamol zezinwele

Ukusetshenziswa kwesihloko samafutha esesame kukondla isikhumba sasekhanda, izintambo zezinwele nemiphini. Lokhu kuthuthukisa ukukhula kwezinwele okunempilo. Iphinde isize ekwelapheni kwanoma yisiphi isikhumba sasekhanda esonakele ngamakhemikhali ngesikhathi sokulashwa kwezinwele noma sokudaya.

Izinwele zangaphambi kwesikhathi zingase zivele ngenxa yekhono elinciphile lomzimba lokwenza i-melanin eyanele, kanye nezinye izinto ezinjengokuxineka kwe-oxidative, indlela yokuphila yokuguqulwa kofuzo kubandakanya nokudla kanye nokusetshenziswa kwezidakamizwa.

Isengezo seSesamol sikhombisile ukuthi sikwazi ukugcina umbala wezinwele kanye nokwenza mnyama izinwele ezivele sezimpunga.

Ngaphandle kwalokho, i-sesamol ingasiza ekuqedeni inkwethu. Ukudonsa kungenzeka ngenxa yesikhumba esomile, ukungezwani komzimba nemikhiqizo yezinwele, nokukhula kwesikhunta esikhumbeni phakathi kwezinye izinto. ISesamol isiza ukondla isikhumba ngaleyo ndlela igcine isikhumba esinempilo ngakho-ke ivimbela ukuvela kwenkwethu. Umsebenzi we-antibacterial uphinde uqinisekise ukuthi isikhumba sasekhanda asinazinto ezincane ezibangela inkwethu.

 

Izindlela ezintathu zokwenziwa ze-sesamole

①. Ukukhishwa emafutheni eSesame

I-sesamol synthesis kusuka ku-Sesame oil kuyindlela elula kunazo zonke kulezi ezintathu. Kodwa-ke, kuyabiza impela. Ngakho-ke le ndlela ayilungele ukukhiqizwa kwezimboni, ikakhulukazi ngenxa yezindleko eziphezulu zokukhiqiza.

 

②. Synthesis synthesis okuvela ku-piperamine

Yize kungumnotho ngokulingana ngesilinganiso esikhulu se-Sesamol Production, yonke indlela yokuhlanganiswa kwe-sesamol kusuka ku-piperamine isebenza ekukhiqizeni ngezinga elincane lapho kuqashwa inqubo ye-hydrolysis ne-hydrolysis. Esimweni esinjalo, ukwakheka kwe-pigment njengokuhlanganisa ukuhlangana kanye nokuphendula okuvela eceleni akunakugwemeka.

 

③. Umzila we-semi-synthetic odabuka ku-jasmonaldehyde

Umzila owenziwe ngokwakhiwa osuselwa eJasmonaldehyde inqubo esetshenziselwa ukusetshenziswa kwe-sesame phenol kakhulu maqondana nezinhloso zezimboni. Inqubo ifaka i-oxidation ne-hydrolysis futhi ngenxa yalokho, i-sesame phenol ephumelelayo ingekhwalithi ephezulu nombala omuhle kakhulu.
Le nqubo isebenzisa ubuchwepheshe bokukhipha obusetshenziswayo futhi obusebenzayo obusebenzisa izindleko, inika amandla ukuhlukaniswa okusheshayo komkhiqizo endaweni yesizinda. Lokhu kunciphisa ukubakhona kokuvela kohlangothi kakhulu. Akumangalisi ukuthi umkhiqizo wokugcina (i-crystal emhlophe emhlophe) usezingeni eliphakeme ngokombala futhi i-sesamol usizi.

 

Kuzo yiwaphi thenga i-sesamol

I-Sesamol powder iyatholakala online kusuka kokuhlukile abakhiqizi be-sesamol. Abasebenzisi abaningi be-sesamol bathenga kokuhlukile amawebhusayithi, ezinye ngezinjongo zokuthengisa noma ezokuthengisa.

Qinisekisa ukuba semthethweni kwakho konke umkhiqizi we-sesamol usebenzisa imithetho yezwe echaziwe ngaphambi kokuthenga.

 

Okubhekwayo

1. UJoo Yeon Kim, uDong Seong Choi noMun Yhung Jung “Umsebenzi we-Antiphoto-oxidative weSesamol eMethylene Blue- kanye neChlorophyll-Sensitized Photo-oxidation of Oil” J. Agric. Ukudla Chem., 51 (11), 3460-3465, 2003.
2. Kumar, Nitesh & Mudgal, Jayesh & Parihar, Vipan & Nayak, Pawan & Nampurath, Gopalan Kutty & Rao, Chamallamudi. (2013). Ukwelashwa kweSesamol Kunciphisa amaPlasma Cholesterol kanye namaleveli e-Triacylglycerol kumaMouse Models we-Acute and Chronic Hyperlipidemia. Ama-lipids. 48. 633-638. 10.1007 / s11745-013-3778-2.
3. Majdalawieh, AF, & Mansour, ZR (2019). I-Sesamol, i-lignan enkulu ezinhlanyelweni ze-sesame (isibonakaliso se-Sesamum): Izakhiwo zokulwa nomdlavuza kanye nezindlela zomsebenzi. I-European Journal ye-Pharmacology, 855, 75-89.INGXENYE: 10.1016 / j.ejphar.2019.05.008.
4. U-Ohsawa, uToshiko. "I-Sesamol ne-sesamol njengama-antioxidants." Imboni Yezokudla Entsha (1991), 33 (6), 1-5.
5. Sesamol Archived 2010-01-14 at Wayback Machine at Chemicalland21.com
6. UWynn, uJames P .; UKendrick, Andrew; URatledge, uColin. "I-Sesamol njengesithibela sokukhula kanye ne-lipid metabolism eMucor circinelloides ngokusebenzisa isenzo sayo ku-enzyme ye-malic." ILipids (1997), 32 (6), 605-610.

 

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